Reticulons bind sphingolipids to activate the endoplasmic reticulum cell cycle checkpoint, the ER surveillance pathway
Summary: The inheritance of a functional endoplasmic reticulum (ER) is ensured by Mind Cards the ER stress surveillance (ERSU) pathway.Here, we made the unexpected discovery that reticulon 1 (Rtn1) and Yop1, well-known ER-curvature-generating proteins, each possess two sphingolipid-binding motifs within their transmembrane domains and that these mo